Jennifer Alexander-Brett, MD, PhD

Jennifer Alexander-Brett, MD, PhD

Assistant Professor of Medicine

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Research Interests

My research interests include the role of epithelial cytokine networks and lung stem cells in development of chronic airway diseases. I employ a variety of techniques including mouse models, analysis of human samples, stem cell biology and biochemical methods. My recent work under the mentorship of Dr. Michael Holtzman has involved the phenotypic and functional characterization of disease-associated IL-33-expressing lung stem cells and their pathogenic role in driving chronic airway disease. As I transition to independence, my research on this cytokine system will focus on the pathway of cellular IL-33 activation, including biochemical and structural definition of nuclear, transcriptional regulatory and extracellular signaling forms of this cytokine. These translational studies will guide efforts toward development of IL-33 antagonists as therapeutics for chronic airway diseases including asthma and COPD.

Education

  • 1995-1999 BS Chemistry & Biochemistry (High Distinction)University of Nebraska-Lincoln, Lincoln, NE
  • 1999-2007 MD, PhD Molecular Biophysics Washington University School of Medicine, St. Louis, MO
  • 2007-2013 Physician-Scientist Training Program, Washington University School of Medicine, St. Louis, MO
  • 2007-2009 Residency, Internal Medicine, ABIM Research Track, Washington University School of Medicine/Barnes Jewish Hospital, St. Louis MO
  • 2009-2011 Fellowship, Pulmonary and Critical Care Medicine, ABIM Research Track, Washington University School of Medicine/Barnes-Jewish Hospital, St. Louis MO
  • 2011-2013 Postdoctoral Research Fellowship, Washington University School of Medicine, St. Louis, MO
  • 2013-2016 Instructor in Medicine
  • 2016-current Assistant Professor of Medicine

Honors and Awards

  • 1999 Phi Beta Kappa National Honor Society
  • 1999 University of Nebraska-Lincoln Chancellor’s Scholar Award
  • 2007 Spencer T. and Ann W. Olin Medical Scientist Fellow Award
  • 2008 Gregory J Gurnter, MD Internal Medicine Resident Research Award
  • 2011 Barnes Jewish Hospital Knowlton Award for Clinical Excellence 2013 American Thoracic Society Early Career Investigator Award
  • 2015 Burroughs Wellcome Career Award for Medical Scientists

Publications

View Jennifer Alexander-Brett’s research publications on PubMed